Dextran 40

€180,00 EUR

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Specification Safety Data Sheet

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Contact Information:
Email: order.maglebiopolymers@maglegroup.com
Phone: +46 40 38 33 00
Address: Københavnsvej 140
4600 Køge
Denmark

Dextran 40 is a biocompatible polysaccharide with medium-range molecular weight, offering enhanced stability in biomedical formulations. It is generally widely used in plasma volume expansion, drug delivery, and hydrogel development.

It is a medium molecular weight dextran (average Mw ≈40,000 Da) which is a highly purified, non-toxic, branched glucose polymer produced via fermentation of Leuconostoc bacteria. Dextran 40 consists of α-D-glucopyranosyl units with predominantly 1,6 glycosidic linkages and a small percentage of 1,3 branches, resulting in a very water-soluble, white to off-white powder.

Widely used as a plasma volume expander – Dextran 40 (often 10% w/v in saline) is infused to treat hypovolemia, increasing blood volume and reducing blood viscosity.
Used for organ preservation solutions during transplantation to protect vascular endothelial surfaces and prevent cell swelling.
Research/Biotech: Utilized in cryopreservation media to protect cells from damage.
Stabilizer for nanoparticles and proteins.

Common Applications

Widely used as a plasma volume expander – Dextran 40 (often 10% w/v in saline) is infused to treat hypovolemia, increasing blood volume and reducing blood viscosity.
Used for organ preservation solutions during transplantation to protect vascular endothelial surfaces and prevent cell swelling.
Research/Biotech: Utilized in cryopreservation media to protect cells from damage.
Stabilizer for nanoparticles and proteins.

Handling & Compatibility

Storage: Powder is slightly hygroscopic; avoid exposure to humid air to prevent clumping. When preparing large volume solutions, add powder slowly to solvent with vigorous stirring to ensure even dissolution.
Sterilization: Sterilize solutions by membrane filtration (0.2 µm) rather than autoclaving to avoid Maillard browning or degradation. Molecular weight may decrease slightly if autoclaved. Gamma irradiation of the dry powder can be used as dextran tolerates gamma sterilization well due to its stable glycosidic bonds.
Compatibility: Highly compatible with saline, glucose, and other common infusion fluids. It can be mixed with other colloids or crystalloids as needed. Avoid mixing with strong bases or strong oxidizers which could degrade the polymer. In formulations, Dextran 40 can be combined with other polymers like hydrolyzed starch or PVP.

Key Properties

Form: Amorphous powder, white to off-white.
Solubility: Highly water-soluble. Insoluble in lower alcohols.
Viscosity: Notable increase compared to lower molecular weight dextrans.
Stability: Very stable in dry form.
Autoclaving of solutions (e.g. 5–10% w/v) is feasible with minimal degradation, although filter-sterilization is preferred to preserve molecular weight.
Resistant to enzymatic breakdown by human amylases (due to branching), and stable over a broad pH range (pH 4–8) in solution.
Available in smaller packs (25-200g) and bulk quantities (> 5kg).

Additional Features

Meets residual solvent criteria.
Kosher and allergen-free status usually available due to non-animal, fermentation origin.